مرجع مواد شیمیایی ایران
اطلاعات عمومی پروپیل پارابن
  • نام شیمیایی

    • پروپیل پارابن

    • Propylparaben

  • مترادف ها
    • propyl 4-hydroxybenzoate ; 4-Hydroxybenzoesäurepropylester ; propyl paraben ; propyl p-hydroxybenzoate ; propyl parahydroxybenzoate ; nipasol ; E216

  • CAS
    94-13-3
  • فرمول مولکولی
    C10H12O3
  • جرم مولکولی
    180/2
  • EINECS
    202-307-7
  • ICB Number
    ICB 5447
  • شکل و حالت فیزیکی
    پودر کریستالی سفید
  • نقطه ذوب
    95-98 °C
  • دانسیته
    1/063 g/cm3
  • ضریب شکست (n20/D­­)
    1/505
  • دمای نگهداری
    0-6 °C
  • حلالیت در آب
    <0/1 g/100 mL at 12 ºC
  • شماره CAS
    94-13-3
  • شماره ثبت تجاری (RBN)
    1103245
  • شماره مرک (Merck)
    14,7866
  • NIST Chemistry Reference
  • EPA Substance Registry System
  • مراجع MSDS
  • ارائه دهنده
    زبان
  • انگلیسی
  • انگلیسی
  • Chemical Properties
    • white crystalline powder

  • General Description
    • Colorless crystals or white powder or chunky white solid. Melting point 95-98°C. Odorless or faint aromatic odor. Low toxicity, Tasteless (numbs the tongue). pH: 6.5-7.0 (slightly acidic) in solution.

  • Reactivity Profile

    Maximum stability of Propylparaben occurs at a pH of 4 to 5. Incompatible with alkalis and iron salts. Also incompatible with strong oxidizing agents and strong acids .

  • Synthesis
    • This product can be derived from the esterification of p-hydroxybenzoic acid and n-propanol. First mix p-hydroxybenzoic acid with propanol and heat to dissolve. Then add sulfuric acid slowly and continue to heat for 8h of refluxion. After cooling, pour them into the 4% sodium carbonate solution for precipitation and crystallization. Filtrate and wash to neutral to obtain the crude product. After further ethanol recrystallization, the finished products are obtained. In the preparation, the cation exchange resin can be used in place of the sulfuric acid catalyst. It can be derived from the esterification of p-hydroxybenzoic acid and n-propanol in the presence of sulfuric acid. Add p-hydroxybenzoic acid and n-propanol in turn to the esterification reactor, and heat to dissolve. Add concentrated sulfuric acid slowly and heat for 8h of refluxion. Pour the reaction solution into 4% sodium carbonate solution before it is cooled. Constantly stir for precipitation and crystallization. Then the crude product can be obtained after centrifugal filtration and washed to neutral. Finally the finished product is acquired after activated carbon decolorization and ethanol recrystallization. The method of preparing ethyl p-hydroxybenzoate can also be used as a reference. HOC6H4COOH + C3H7OH [H2SO4] → HOC6H4COOC3H7 + H2O

  • Usage
    • 1. Propylparaben Used as preservatives and antioxidants, and also used in the pharmaceutical industry 2. Used as the antimicrobial preservative in pharmaceuticals and cosmetics 3. According to ethyl p-hydroxybenzoate (17007) 4. Used as antiseptic and antimicrobial. 5. Used as the preservatives of food, cosmetics and medicines.

  • Fire Hazard

    Flash point data for Propylparaben are not available; however, Propylparaben is probably combustible.

  • Raw materials

    Sulfuric acid -->4-Hydroxybenzoic acid-->1-Propanol-->Ethylparaben